I often ran into the issue when testing and debugging web applications and sites that I would often have to clear cookies and caches in order to effectively work.
This tip posted by Scott Hanselman is a good one, I had not heard of, let alone thought of. In his post he talks about adding Chrome in incognito mode and Internet Explorer in private mode to Visual Studio. Both of these effectively means any cookies or cached data you create during that session would/should be removed when you close that browser. This should make it easier than having to manually clear that data when testing.